Optimization of streptomycete strains producing polyether and macrolide antibiotics.
نویسندگان
چکیده
screened for high-frequency transfer of OTC resistance. Although such strains were found at quite a high frequency (about 1 in IOOO), it was subsequently discovered that a second plasmid SRP2 had actually been primed. This possessed much weaker sex-factor activity than SRPl . Neither plasmid has proved amenable to physical isolation or analysis, and with the advent of recombinant DNA techniques it was decided to clone the OTC genes onto specifically developed cloning vectors.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 12 4 شماره
صفحات -
تاریخ انتشار 1984